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Article

Development and prevalence of castration-resistant prostate cancer subtypes

25 Sept 2020

Abstract excerpt

BACKGROUND: Castration-resistant prostate cancer (CRPC) occurs when prostate cancer (CaP) progresses under therapy-induced castrate conditions. Several mechanisms have been proposed to explain this acquired resistance, many of which are driven by androgen receptor (AR). Recent findings, however, sub-classified CRPC by downregulation/absence of AR in certain subtypes that consequently do not respond to...

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PMID: 32980775
DOI: 10.1016/j.neo.2020.09.002

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