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Article

An integrin-alpha4-14-3-3zeta-paxillin ternary complex mediates localised Cdc42 activity and accelerates cell migration.

Journal of cell science - 15 May 2009

Deakin Nicholas O, Bass Mark D, Warwood Stacey, Schoelermann Julia, Mostafavi-Pour Zohreh, Knight David, Ballestrem Christoph, Humphries Martin J

Abstract excerpt

Alpha4 integrins are used by leukocytes and neural crest derivatives for adhesion and migration during embryogenesis, immune responses and tumour invasion. The pro-migratory activity of alpha4 integrin is mediated in part through the direct binding of the cytoplasmic domain to paxillin. Here, using intermolecular FRET and biochemical analyses, we report a novel interaction of the alpha4 integrin cytoplasmic...

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Source

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Identifiers

PMID: 19401330
DOI: 10.1242/jcs.049130
PMCID: PMC2680104

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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