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Article

Engineering the DNA cytosine-5 methyltransferase reaction for sequence-specific labeling of DNA.

Nucleic acids research - 1 Dec 2012

Lukinavicius Grazvydas, Lapinaite Audrone, Urbanaviciute Giedre, Gerasimaite Ruta, Klimasauskas Saulius

Abstract excerpt

DNA methyltransferases catalyse the transfer of a methyl group from the ubiquitous cofactor S-adenosyl-L-methionine (AdoMet) onto specific target sites on DNA and play important roles in organisms from bacteria to humans. AdoMet analogs with extended propargylic side chains have been chemically produced for methyltransferase-directed transfer of activated groups (mTAG) onto DNA, although the efficiency of...

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Identifiers

PMID: 23042683
DOI: 10.1093/nar/gks914
PMCID: PMC3526304

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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