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Article

Foxp1 controls brown/beige adipocyte differentiation and thermogenesis through regulating β3-AR desensitization

7 Nov 2019

Abstract excerpt

β-Adrenergic receptor (β-AR) signaling is a pathway controlling adaptive thermogenesis in brown or beige adipocytes. Here we investigate the biological roles of the transcription factor Foxp1 in brown/beige adipocyte differentiation and thermogenesis. Adipose-specific deletion of Foxp1 leads to an increase of brown adipose activity and browning program of white adipose tissues. The Foxp1-deficient mice show an...

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Share to Adipokines, Inflammation, and Metabolic Diseases
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PMID: 31699980
DOI: 10.1038/s41467-019-12988-8

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