Article
Egr1 deficiency induces browning of inguinal subcutaneous white adipose tissue in mice
17 Nov 2017
Abstract excerpt
Beige adipocyte differentiation within white adipose tissue, referred to as browning, is seen as a possible mechanism for increasing energy expenditure. The molecular regulation underlying the thermogenic browning process has not been entirely elucidated. Here, we identify the zinc finger transcription factor EGR1 as a negative regulator of the beige fat program. Loss of Egr1 in mice promotes browning in the...
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