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Article

Integrative Analyses Followed by Functional Characterization Reveal TMEM180 as a Schizophrenia Risk Gene.

Schizophrenia bulletin - 21 Aug 2021

Wang Jun-Yang, Li Xiao-Yan, Li Hui-Juan, Liu Jie-Wei, Yao Yong-Gang, Li Ming, Xiao Xiao, Luo Xiong-Jian

Abstract excerpt

Recent large-scale integrative analyses (including Transcriptome-Wide Association Study [TWAS] and Summary-data-based Mendelian Randomization [SMR]) have identified multiple genes whose cis-regulated expression changes may confer risk of schizophrenia. Nevertheless, expression quantitative trait loci (eQTL) data and genome-wide associations used for integrative analyses were mainly from populations of European...

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PMID: 33768244
DOI: 10.1093/schbul/sbab032
PMCID: PMC8379544

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