Article

Endogamy and high prevalence of deleterious mutations in India: evidence from strong founder events

2024-08-29

Abstract excerpt

Founder events influence recessive diseases in highly endogamous populations. Several Indian populations have experienced significant founder events and maintained strict endogamy. Genomic studies in Indian populations often lack in addressing clinical implications of these phenomena. We performed whole-exome sequencing of 281 individuals from four South Indian groups to evaluate population-specific disease causin...

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Literature Corpus work: cfd231a9-c13a-55a7-8196-1be8f9a5d77c
DOI: 10.1101/2024.08.21.24312342

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