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Article

Microtubule-mediated transport of the tumor-suppressor protein Merlin and its mutants

5 Apr 2010

Abstract excerpt

The neurofibromatosis type 2 (NF2) tumor-suppressor protein Merlin is a member of the ERM family of proteins that links the cytoskeleton to the plasma membrane. In humans, mutations in the NF2 gene cause neurofibromatosis type-2 (NF2), a cancer syndrome characterized by the development of tumors of the nervous system. Previous reports have suggested that the subcellular distribution of Merlin is critical to its...

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PMID: 20368450
DOI: 10.1073/pnas.0907389107

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