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Article

Structural basis for neurofibromatosis type 2. Crystal structure of the merlin FERM domain.

The Journal of biological chemistry - 22 Mar 2002

Shimizu Toshiyuki, Seto Azusa, Maita Nobuo, Hamada Keisuke, Tsukita Shoichiro, Tsukita Sachiko, Hakoshima Toshio

Abstract excerpt

Neurofibromatosis type 2 (NF2) is a dominantly inherited disease associated with the central nervous system. The NF2 gene product merlin is a tumor suppressor, and its mutation or inactivation causes this disease. We report here the crystal structure of the merlin FERM domain containing a 22-residue alpha-helical segment. The structure reveals that the merlin FERM domain consists of three subdomains displaying...

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Identifiers

PMID: 11756419
DOI: 10.1074/jbc.M109979200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Structural basis for neurofibromatosis type 2. Crystal structure of the merlin FERM domain.PMID 11756419Read ↗

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