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Article

Structural basis of the binding of Merlin FERM domain to the E3 ubiquitin ligase substrate adaptor DCAF1.

The Journal of biological chemistry - 23 May 2014

Li Youjun, Wei Zhiyi, Zhang Junyi, Yang Zhou, Zhang Mingjie

Abstract excerpt

The tumor suppressor gene Nf2 product, Merlin, plays vital roles in controlling proper development of organ sizes by specifically binding to a large number of target proteins localized both in cytoplasm and nuclei. The FERM domain of Merlin is chiefly responsible for its binding to target proteins, although the molecular basis governing these interactions are poorly understood due to lack of structural...

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Source

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Identifiers

PMID: 24706749
DOI: 10.1074/jbc.M114.551184
PMCID: PMC4031523

Genes

DCAF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Structural basis of the binding of Merlin FERM domain to the E3 ubiquitin ligase substrate adaptor DCAF1.PMID 24706749Read ↗

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