Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic Polymorphisms in DNA Repair Gene APE1/Ref-1 and the Risk of Neural Tube Defects in a High-Risk Area of China.

Reproductive sciences (Thousand Oaks, Calif.) - 1 Sept 2021

Wang Xiuwei, Yue Huixuan, Li Shen, Guo Jin, Guan Zhen, Zhu Zhiqiang, Niu Bo, Zhang Ting, Wang Jianhua

Abstract excerpt

Apurinic/apyrimidinic endonuclease 1/redox-factor 1 (APE1/Ref-1) gene encodes a multifunctional protein involved in the DNA base excision repair (BER) pathway, which initiates repair of apurinic/apyrimidinic (AP) sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone. APE1/Ref-1 polymorphisms are related to the occurrence of neural tube defects (NTDs), but the association between APE1/Ref-1...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Asian People
Share to Biomarkers

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA-(Apurinic or Apyrimidinic Site) Lyase

Share to Folic Acid

Share to Genetic Association Studies

Share to Neural Tube Defects

Share to Risk Assessment

Source

Identifiers

PMID: 33761125
DOI: 10.1007/s43032-021-00537-y

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic Polymorphisms in DNA Repair Gene APE1/Ref-1 and the Risk of Neural Tube Defects in a High-Risk Area of China.PMID 33761125Read ↗

A genetic variant in the APE1/Ref-1 gene promoter -141T/G may modulate risk of glioblastoma in a Chinese Han population.Semantic proximity Read ↗

Neural Tube Defects and Folate Deficiency: Is DNA Repair Defective?Semantic proximity Read ↗

Apurinic endonuclease-1 preserves neural genome integrity to maintain homeostasis and thermoregulation and prevent brain tumorsSemantic proximity Read ↗

APE1/Ref-1 Role in Inflammation and Immune ResponseSemantic proximity Read ↗

DNA damage response in neurodevelopment and neuromaintenanceSemantic proximity Read ↗

Polymorphism rs1052536 in Base Excision Repair Gene Is a Risk Factor in a High-Risk Area of Neural Tube Defects in China.Semantic proximity Read ↗

Polymorphisms in MTHFD1 Gene and Susceptibility to Neural Tube Defects: A Case-Control Study in a Chinese Han Population with Relatively Low Folate Levels.Semantic proximity Read ↗

Correlation analysis of MTHFD1 gene polymorphisms and neural tube defects in Han population of Northern ChinaSemantic proximity Read ↗

Variants in MTHFR gene and neural tube defects susceptibility in China.Semantic proximity Read ↗

Haplotype-based case-control study on human apurinic/apyrimidinic endonuclease 1/redox effector factor-1 gene and essential hypertension.Semantic proximity Read ↗

Low folate concentration impacts mismatch repair deficiency in neural tube defects.Semantic proximity Read ↗

Association of main folate metabolic pathway gene polymorphisms with neural tube defects in Han population of Northern China.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.