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Article

Polymorphism rs1052536 in Base Excision Repair Gene Is a Risk Factor in a High-Risk Area of Neural Tube Defects in China.

Medical science monitor : international medical journal of experimental and clinical research - 19 Jul 2018

Li Guannan, Wang Xin, Wang Xiuwei, Guan Zhen, Guo Jin, Wang Fang, Zhang Jianzhao, Niu Bo, Zhang Ting, Wang Jianhua, Yang Jian

Abstract excerpt

BACKGROUND DNA Base Excision Repair Gene-DNA LigaseIII (LIG3) is an important repair gene in the repair pathway and plays an important role in maintaining the integrity of mitochondria. Rs1052536 and rs3135967 polymorphisms of the gene are associated with lung cancer, keratoconus, and Fuchs endothelial corneal dystrophy. There is no previously published report on the relationship between the polymorphisms and...

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PMID: 30022792
DOI: 10.12659/MSM.907492
PMCID: PMC6067017

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LIG3

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