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Article

Functional characterization of PIK3CA E545A mutation in MCF-7 breast cancer cells reveals enhanced proliferation and resistance to Alpelisib.

Biochemical and biophysical research communications - 3 Sept 2026

Le Hoai Thu, Nghi Nguyen Bao, My Vu Diem, Vu Hoang Anh, Thanh Ma Chi, Tri Bui Minh, Niem Vo Van Thanh, Phuong Huynh Anh

Abstract excerpt

PIK3CA mutations are central oncogenic drivers in hormone receptor-positive, HER2-negative breast cancer; however, the functional and therapeutic relevance of noncanonical variants remains incompletely defined. The E545A mutation, increasingly reported in specific patient populations, has not been systematically investigated. We generated an isogenic MCF-7 cell model harboring the PIK3CA E545A mutation using...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42341421
DOI: 10.1016/j.bbrc.2026.154189

Genes

PIK3CA

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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