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The evolutionary history of ACE2 usage within the coronavirus subgenus Sarbecovirus

1 Jan 2021

Abstract excerpt

Severe acute respiratory syndrome coronavirus 1 (SARS-CoV-1) and SARS-CoV-2 are not phylogenetically closely related; however, both use the angiotensin-converting enzyme 2 (ACE2) receptor in humans for cell entry. This is not a universal sarbecovirus trait; for example, many known sarbecoviruses related to SARS-CoV-1 have two deletions in the receptor binding domain of the spike protein that render them incapable...

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PMID: 33754082
DOI: 10.1093/ve/veab007

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