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Article

Evolutionary and codon usage preference insights into spike glycoprotein of SARS-CoV-2.

Briefings in bioinformatics - 22 Mar 2021

Malik Yashpal Singh, Ansari Mohd Ikram, Kattoor Jobin Jose, Kaushik Rahul, Sircar Shubhankar, Subbaiyan Anbazhagan, Tiwari Ruchi, Dhama Kuldeep, Ghosh Souvik, Tomar Shailly, Zhang Kam Y J

Abstract excerpt

Interaction of SARS-CoV-2 spike glycoprotein with the ACE2 cell receptor is very crucial for virus attachment to human cells. Selected mutations in SARS-CoV-2 S-protein are reported to strengthen its binding affinity to mammalian ACE2. The N501T mutation in SARS-CoV-2-CTD furnishes better support to hotspot 353 in comparison with SARS-CoV and shows higher affinity for receptor binding. Recombination analysis...

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Share to Angiotensin-Converting Enzyme 2
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Spike Glycoprotein, Coronavirus

Source

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Identifiers

PMID: 33377145
DOI: 10.1093/bib/bbaa383
PMCID: PMC7953982

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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