Article
Effects of KRAS Genetic Interactions on Outcomes in Cancers of the Lung, Pancreas, and Colorectum.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 9 Jan 2024
Grabski Isabella N, Heymach John V, Kehl Kenneth L, Kopetz Scott, Lau Ken S, Riely Gregory J, Schrag Deborah, Yaeger Rona, Irizarry Rafael A, Haigis Kevin M
Abstract excerpt
BACKGROUND: KRAS is among the most commonly mutated oncogenes in cancer, and previous studies have shown associations with survival in many cancer contexts. Evidence from both clinical observations and mouse experiments further suggests that these associations are allele- and tissue-specific. These findings motivate using clinical data to understand gene interactions and clinical covariates within different...
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