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Histology-based molecular profiling improves mutation detection for advanced thyroid cancer.

Genes, chromosomes & cancer - 1 Aug 2021

Eszlinger Markus, Khalil Moosa, Gillmor Aaron Hill, Huang Helen, Stewardson Paul, McIntyre John B, Morrissy Sorana, Paschke Ralf

Abstract excerpt

Advanced cancers frequently show histologic and molecular intratumoral heterogeneity. Therefore, we comprehensively characterized advanced, metastatic, radioiodine-resistant (RAIR) thyroid carcinomas at the molecular level in the context of histologic heterogeneity with the aim to identify potentially actionable mutations that may guide the use of specific tyrosine kinase inhibitor (TKI) treatment. Whole exome...

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Identifiers

PMID: 33749950
DOI: 10.1002/gcc.22949

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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