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Article

Identification of differential DNA methylation alterations of ovarian cancer in peripheral whole blood based on within-sample relative methylation orderings.

Epigenetics - 1 Mar 2022

Li Hongdong, Jiang Fengle, Du Yuhui, Li Na, Chen Zhihong, Cai Hao, Guo You, Hong Guini

Abstract excerpt

Leukocyte cell proportion changes affect the detection of cancer-associated aberrant DNA methylation alterations in peripheral blood samples. We aimed to detect cellular DNA methylation changes in ovarian cancer (OVC) blood samples avoiding the above-mentioned cell-composition effects. Based on the within-sample relative methylation orderings (RMOs) of CpG loci in leukocyte subtypes, we developed the Ref-RMO...

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Identifiers

PMID: 33749504
DOI: 10.1080/15592294.2021.1900029
PMCID: PMC8920127

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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