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Germline sexual fate is determined by the antagonistic action of dmrt1 and foxl3/foxl2 in tilapia

19 Mar 2021

Abstract excerpt

Germline sexual fate has long been believed to be determined by the somatic environment, but this idea is challenged by recent studies of foxl3 mutants in medaka. Here, we demonstrate that the sexual fate of tilapia germline is determined by the antagonistic interaction of dmrt1 and foxl3, which are transcriptionally repressed in male and female germ cells, respectively. Loss of dmrt1 rescued the germ cell sex...

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PMID: 33741713
DOI: 10.1242/dev.199380

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Germline sexual fate is determined by the antagonistic action of dmrt1 and foxl3/foxl2 in tilapiaPMID 33741713Read ↗

Dmrt1 is the only male pathway gene tested indispensable for sex determination and functional testis development in tilapiaSemantic proximity Read ↗

<i>gsdf</i> is a downstream gene of <i>dmrt1</i> that functions in the male sex determination pathway of the Nile tilapiaSemantic proximity Read ↗

Antagonistic roles of Dmrt1 and Foxl2 in sex differentiation via estrogen production in tilapia as demonstrated by TALENs.Semantic proximity Read ↗

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miR-202 drives medaka fertility by targeting antagonistic Yap-dependent transcriptional regulators <i>tead3b</i> and <i>vgll4b</i> in a sex-dependent mannerSemantic proximity Read ↗

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Dietary aromatase inhibitor treatment converts XY gsdf homozygous mutants to sub-fertile male in Nile tilapia (Oreochromis niloticus)Semantic proximity Read ↗

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Mutation of foxl2 or cyp19a1a Results in Female to Male Sex Reversal in XX Nile Tilapia.Semantic proximity Read ↗

The Mechanism of Germline Sex Determination in VertebratesSemantic proximity Read ↗

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