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Steroid hormone-deprived sex reversal in cyp11a1 mutant XX tilapia experiences an ovary-like stage at molecular level.

Communications biology - 16 Sept 2024

Xiao Hesheng, Wang Leihui, Yan Shuo, Ma He, Xu Zhen, Wang Feilong, Wang Jingrong, Tao Wenjing, Wang Deshou

Abstract excerpt

Fish sex is largely influenced by steroid hormones, especially sex hormones. Here, we established a steroid hormone-free genetic model by mutation of cyp11a1 in Nile tilapia, which was confirmed by EIA assay. Gonadal phenotype and transcriptome analyses showed that the XX mutants displayed sex reversal from female to male but with defective spermatogenesis. Despite the sex reversal, the aromatase encoding gene...

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Cholesterol Side-Chain Cleavage Enzyme
Cichlids
Disorders of Sex Development
Fish Proteins
Gonadal Steroid Hormones

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Sex Determination Processes

Sex Differentiation

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PMID: 39284885
DOI: 10.1038/s42003-024-06853-8
PMCID: PMC11405705

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Steroid hormone-deprived sex reversal in cyp11a1 mutant XX tilapia experiences an ovary-like stage at molecular level.PMID 39284885Read ↗

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Mutation of foxl2 or cyp19a1a Results in Female to Male Sex Reversal in XX Nile Tilapia.Semantic proximity Read ↗

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dmrt1 Is Responsible for Androgen-Induced Masculinization in Nile Tilapia.Semantic proximity Read ↗

Dmrt1 is the only male pathway gene tested indispensable for sex determination and functional testis development in tilapiaSemantic proximity Read ↗

Dietary aromatase inhibitor treatment converts XY gsdf homozygous mutants to sub-fertile male in Nile tilapia (Oreochromis niloticus)Semantic proximity Read ↗

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<i>gsdf</i> is a downstream gene of <i>dmrt1</i> that functions in the male sex determination pathway of the Nile tilapiaSemantic proximity Read ↗

Disruption of dmrt1 rescues the all-male phenotype of the cyp19a1a mutant in zebrafish - a novel insight into the roles of aromatase/estrogens in gonadal differentiation and early folliculogenesis.Semantic proximity Read ↗

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