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Article

Antagonistic roles of Dmrt1 and Foxl2 in sex differentiation via estrogen production in tilapia as demonstrated by TALENs.

Endocrinology - 1 Dec 2013

Li Ming-Hui, Yang Hui-Hui, Li Meng-Ru, Sun Yun-Lv, Jiang Xiao-Long, Xie Qing-Ping, Wang Ting-Ru, Shi Hong-Juan, Sun Li-Na, Zhou Lin-Yan, Wang De-Shou

Abstract excerpt

Transcription activator-like effector nucleases (TALENs) are a powerful approach for targeted genome editing and have been proved to be effective in several organisms. In this study, we reported that TALENs can induce somatic mutations in Nile tilapia, an important species for worldwide aquaculture, with reliably high efficiency. Six pairs of TALENs were constructed to target genes related to sex differentiation,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24105480
DOI: 10.1210/en.2013-1451

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Antagonistic roles of Dmrt1 and Foxl2 in sex differentiation via estrogen production in tilapia as demonstrated by TALENs.PMID 24105480Read ↗

Mutation of foxl2 or cyp19a1a Results in Female to Male Sex Reversal in XX Nile Tilapia.Semantic proximity Read ↗

<i>gsdf</i> is a downstream gene of <i>dmrt1</i> that functions in the male sex determination pathway of the Nile tilapiaSemantic proximity Read ↗

Homozygous Mutation of gsdf Causes Infertility in Female Nile Tilapia (Oreochromis niloticus).Semantic proximity Read ↗

Dmrt1 is the only male pathway gene tested indispensable for sex determination and functional testis development in tilapiaSemantic proximity Read ↗

Steroid hormone-deprived sex reversal in cyp11a1 mutant XX tilapia experiences an ovary-like stage at molecular level.Semantic proximity Read ↗

Dietary aromatase inhibitor treatment converts XY gsdf homozygous mutants to sub-fertile male in Nile tilapia (Oreochromis niloticus)Semantic proximity Read ↗

Doublesex- and Mab-3-Related Transcription Factor-1 Repression of Aromatase Transcription, a Possible Mechanism Favoring the Male Pathway in TilapiaSemantic proximity Read ↗

Homozygous mutation of foxh1 arrests oogenesis causing infertility in female Nile tilapia†.Semantic proximity Read ↗

Haploinsufficiency of SF-1 Causes Female to Male Sex Reversal in Nile Tilapia, Oreochromis niloticusSemantic proximity Read ↗

Cyp17a1 is Required for Female Sex Determination and Male Fertility by Regulating Sex Steroid Biosynthesis in FishSemantic proximity Read ↗

dmrt1 Is Responsible for Androgen-Induced Masculinization in Nile Tilapia.Semantic proximity Read ↗

Heterozygous mutation of eEF1A1b resulted in spermatogenesis arrest and infertility in male tilapia, Oreochromis niloticus.Semantic proximity Read ↗

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