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Article

Purified Protein Delivery to Activate an Epigenetically Silenced Allele in Mouse Brain.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2018

Pyles Benjamin, Bailus Barbara J, O'Geen Henriette, Segal David J

Abstract excerpt

The ability to activate or repress specific genes in the brain could have a tremendous impact for understanding and treating neurological disorders. Artificial transcription factors based on zinc finger, TALE, and CRISPR/Cas9 programmable DNA-binding platforms have been widely used to regulate the expression of specific genes in cultured cells, but their delivery into the brain represents a critical challenge to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29524138
DOI: 10.1007/978-1-4939-7774-1_12
PMCID: PMC6281562

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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