Article
Lack of Mucosal Cholinergic Innervation Is Associated With Increased Risk of Enterocolitis in Hirschsprung's Disease.
Cellular and molecular gastroenterology and hepatology - 1 Jan 2021
Keck Simone, Galati-Fournier Virginie, Kym Urs, Moesch Michèle, Usemann Jakob, Müller Isabelle, Subotic Ulrike, Tharakan Sasha J, Krebs Thomas, Stathopoulos Eleuthere, Schmittenbecher Peter, Cholewa Dietmar, Romero Philipp, Reingruber Bertram, Bruder Elisabeth, Group Nig Study, Holland-Cunz Stefan
Abstract excerpt
BACKGROUND & AIMS: Hirschsprung's disease (HSCR) is a congenital intestinal motility disorder defined by the absence of enteric neuronal cells (ganglia) in the distal gut. The development of HSCR-associated enterocolitis remains a life-threatening complication. Absence of enteric ganglia implicates innervation of acetylcholine-secreting (cholinergic) nerve fibers. Cholinergic signals have been reported to control...
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