Article

Lack of mucosal cholinergic innervation is associated with increased risk of enterocolitis in Hirschsprung’s disease

2020-06-15

Abstract excerpt

<h4>Background & Aims</h4> Hirschsprung’s disease (HSCR) is a congenital intestinal motility disorder defined by the absence of enteric nervous cells (ganglia). The development of HSCR-associated enterocolitis remains a life-threatening complication. Absence of enteric ganglia implicates extramural innervation of acetylcholine-secreting (cholinergic) nerve fibers. Cholinergic signals have been reported to control...

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Literature Corpus work: 094c5545-8744-547a-98e5-1ec280339aad
DOI: 10.1101/2020.06.15.151621

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