GARSA: An integrative pipeline for genome wide association studies and polygenic risk score inference in admixed human populations

Abstract excerpt

Genome-wide association studies (GWAS) and polygenic risk scores (PRS) are multistep analytical tools to identify genetic variants and to assess their contribution to phenotypes/diseases. These analyses are evolving and becoming instrumental to understand the genetic architecture of complex phenotypes/diseases. Nevertheless, to date, there is no single solution incorporating all major steps related to those analys...

Topics

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• Data Interpretation, Statistical
• Genetic Predisposition to Disease
• Genome-Wide Association Study
• Guidelines as Topic
• Multifactorial Inheritance
• Polymorphism, Single Nucleotide
• Quality Control
• Risk Assessment

Identifiers and source

Literature Corpus work

7bbeb183-250d-5ed4-9ccc-799849f80369

DOI

10.1101/2023.05.03.539305