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Article

General regression model: A "model-free" association test for quantitative traits allowing to test for the underlying genetic model.

Annals of human genetics - 1 May 2020

Gloaguen Emilie, Dizier Marie-Hélène, Boissel Mathilde, Rocheleau Ghislain, Canouil Mickaël, Froguel Philippe, Tichet Jean, Roussel Ronan, Julier Cécile, Balkau Beverley, Mathieu Flavie

Abstract excerpt

Most genome-wide association studies used genetic-model-based tests assuming an additive mode of inheritance, leading to underpowered association tests in case of departure from additivity. The general regression model (GRM) association test proposed by Fisher and Wilson in 1980 makes no assumption on the genetic model. Interestingly, it also allows formal testing of the underlying genetic model. We conducted a...

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PMID: 31834638
DOI: 10.1111/ahg.12372

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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