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Article

Validity of a seven-gene signature as a non-invasive biomarker for cirrhosis: a cross-sectional study in Egyptian patients with HBV infection.

BMC gastroenterology - 1 Jun 2026

El-Kader Ahlam Abd, El-Meguid Mai Abd, Zayed Naglaa, Alem Shereen Abdel, Barkat Ahmed, Dawood Reham M

Abstract excerpt

BACKGROUND: Hepatitis B virus (HBV) infection poses a significant public health challenge, leading to liver cirrhosis and hepatocellular carcinoma (HCC). The clinical course of HBV infection is influenced by viral, environmental, and host genetic variants. Recently, a Cirrhosis Risk Score (CRS) based on seven genetic variants has been developed to identify individuals at risk of developing cirrhosis. This study...

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Source

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Identifiers

PMID: 42226117
DOI: 10.1186/s12876-026-04812-7
PMCID: PMC13224460

Genes

DEGS1
STXBP5L
AQP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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