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Article

Validity of a seven-gene signature as a non-invasive biomarker for cirrhosis: a cross-sectional study in Egyptian patients with HBV infection.

BMC gastroenterology - 1 Jun 2026

El-Kader Ahlam Abd, El-Meguid Mai Abd, Zayed Naglaa, Alem Shereen Abdel, Barkat Ahmed, Dawood Reham M

Abstract excerpt

BACKGROUND: Hepatitis B virus (HBV) infection poses a significant public health challenge, leading to liver cirrhosis and hepatocellular carcinoma (HCC). The clinical course of HBV infection is influenced by viral, environmental, and host genetic variants. Recently, a Cirrhosis Risk Score (CRS) based on seven genetic variants has been developed to identify individuals at risk of developing cirrhosis. This study...

Topics

Humans
Liver Cirrhosis
Cross-Sectional Studies
Egypt
Male
Female
Biomarkers
Polymorphism, Single Nucleotide
Middle Aged
Adult
Hepatitis B, Chronic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genotype

Disease Progression

ROC Curve

Hepatitis B

Predictive Value of Tests

Source

Open in PubMed Open full text

Identifiers

PMID: 42226117
DOI: 10.1186/s12876-026-04812-7
PMCID: PMC13224460

Genes

DEGS1
STXBP5L
AQP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-42226117-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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