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Reduced pathogenicity of fructose-1,6-bisphosphatase deficient Leishmania donovani and its use as an attenuated strain to induce protective immunogenicity.

Vaccine - 21 Feb 2018

Saini Savita, Ghosh Ayan Kumar, Das Sushmita, Singh Ruby, Abhishek Kumar, Verma Sudha, Kumar Ajay, Mandal Abhishek, Purkait Bidyut, Sinha Kislay Kumar, Das Pradeep

Abstract excerpt

Currently, there is no approved vaccine for visceral leishmaniasis (VL) caused by L. donovani. The ability to manipulate Leishmania genome by eliminating or introducing genes necessary for parasites' survival considered as the powerful strategy to generate the live attenuated vaccine. In the present study fructose-1,6-bisphosphatase (LdFBPase) gene deleted L. donovani (Δfbpase) was generated using homologous gene...

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PMID: 29395522
DOI: 10.1016/j.vaccine.2018.01.032

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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