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Article

Factor H-related proteins determine complement-activating surfaces.

Trends in immunology - 1 Jun 2015

Józsi Mihály, Tortajada Agustin, Uzonyi Barbara, Goicoechea de Jorge Elena, Rodríguez de Córdoba Santiago

Abstract excerpt

Complement factor H-related proteins (FHRs) are strongly associated with different diseases involving complement dysregulation, which suggests a major role for these proteins regulating complement activation. Because FHRs are evolutionarily and structurally related to complement inhibitor factor H (FH), the initial assumption was that the FHRs are also negative complement regulators. Whereas weak complement...

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Identifiers

PMID: 25979655
DOI: 10.1016/j.it.2015.04.008

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