Article

TFEB/Mitf links impaired nuclear import to autophagolysosomal dysfunction in C9-ALS

2020-06-26

Abstract excerpt

Disrupted nucleocytoplasmic transport (NCT) has been implicated in neurodegenerative disease pathogenesis; however, the mechanisms by which impaired NCT causes neurodegeneration remain unclear. In a Drosophila screen, we identified Ref(2)p/p62, a key regulator of autophagy, as a potent suppressor of neurodegeneration caused by the GGGGCC hexanucleotide repeat expansion (G4C2 HRE) in C9orf72 that causes amyotrophi...

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Literature Corpus work: c123bb24-6305-5223-ae24-779e87814b1d
DOI: 10.1101/2020.06.26.173021

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