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Identification of novel ATP13A2 interactors and their role in α-synuclein misfolding and toxicity

29 May 2012

Abstract excerpt

Lysosomes are responsible for degradation and recycling of bulky cell material, including accumulated misfolded proteins and dysfunctional organelles. Increasing evidence implicates lysosomal dysfunction in several neurodegenerative disorders, including Parkinson's disease and related synucleinopathies, which are characterized by the accumulation of α-synuclein (α-syn) in Lewy bodies. Studies of lysosomal...

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PMID: 22645275
DOI: 10.1093/hmg/dds206

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