Article
Oocyte age and preconceptual alcohol use are highly correlated with epigenetic imprinting of a noncoding RNA (nc886).
Proceedings of the National Academy of Sciences of the United States of America - 23 Mar 2021
Carpenter Brittany L, Remba Tanaka K, Thomas Stacey L, Madaj Zachary, Brink Lucy, Tiedemann Rochelle L, Odendaal Hein J, Jones Peter A
Abstract excerpt
Genomic imprinting occurs before fertilization, impacts every cell of the developing child, and may be sensitive to environmental perturbations. The noncoding RNA, nc886 (also called VTRNA2-1) is the only known example of the ∼100 human genes imprinted by DNA methylation, that shows polymorphic imprinting in the population. The nc886 gene is part of an ∼1.6-kb differentially methylated region (DMR) that is...
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