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Article

Immediate and durable effects of maternal tobacco consumption alter placental DNA methylation in enhancer and imprinted gene-containing regions

7 Oct 2020

Abstract excerpt

BACKGROUND: Although exposure to cigarette smoking during pregnancy has been associated with alterations of DNA methylation in the cord blood or placental cells, whether such exposure before pregnancy could induce epigenetic alterations in the placenta of former smokers has never been investigated. METHODS: Our approach combined the analysis of placenta epigenomic (ENCODE) data with newly generated DNA...

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PMID: 33023569
DOI: 10.1186/s12916-020-01736-1

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