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Article

Designed improvement to T-cell immunotherapy by multidimensional single cell profiling.

Journal for immunotherapy of cancer - 1 Mar 2021

Bandey Irfan N, Adolacion Jay R T, Romain Gabrielle, Paniagua Melisa Martinez, An Xingyue, Saeedi Arash, Liadi Ivan, You Zheng, Rajanayake Rasindu B, Hwu Patrick, Singh Harjeet, Cooper Laurence Jn, Varadarajan Navin

Abstract excerpt

BACKGROUND: Adoptive cell therapy based on the infusion of chimeric antigen receptor (CAR) T cells has shown remarkable efficacy for the treatment of hematologic malignancies. The primary mechanism of action of these infused T cells is the direct killing of tumor cells expressing the cognate antigen. However, understanding why only some T cells are capable of killing, and identifying mechanisms that can improve...

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Identifiers

PMID: 33722906
DOI: 10.1136/jitc-2020-001877
PMCID: PMC7970283

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