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Article

Single-cell genomic approaches for developing the next generation of immunotherapies.

Nature medicine - 1 Feb 2020

Yofe Ido, Dahan Rony, Amit Ido

Abstract excerpt

Recent progress in single-cell genomics urges its application in drug development, particularly of cancer immunotherapies. Current immunotherapy pipelines are focused on functional outcome and simple cellular and molecular readouts. A thorough mechanistic understanding of the cells and pathways targeted by immunotherapy agents is lacking, which limits the success rate of clinical trials. A large leap forward can...

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PMID: 32015555
DOI: 10.1038/s41591-019-0736-4

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