Mutations in the HIV-1 3′-Polypurine Tract and Integrase Strand Transfer Inhibitor Resistance

Abstract excerpt

Integrase strand transfer inhibitors (INSTIs), in combination with other antivirals, are widely used for the treatment of HIV-1-infected individuals. HIV-1 resistance to INSTIs is typically associated with mutations in the viral integrase gene (1). However, recent studies suggested that mutations in the HIV-1 3′-polypurine tract (3′-PPT) may also confer viral resistance to INSTIs. Specifically, Malet et al. (2)...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Biochemical and Molecular Research
• Share to HIV/AIDS drug development and treatment
• Share to HIV Research and Treatment