Article
HIV-1 Resistance Dynamics in Patients With Virologic Failure to Dolutegravir Maintenance Monotherapy.
The Journal of infectious diseases - 24 Jul 2018
Wijting Ingeborg E A, Lungu Cynthia, Rijnders Bart J A, van der Ende Marchina E, Pham Hanh T, Mesplede Thibault, Pas Suzan D, Voermans Jolanda J C, Schuurman Rob, van de Vijver David A M C, Boers Patrick H M, Gruters Rob A, Boucher Charles A B, van Kampen Jeroen J A
Abstract excerpt
Background: A high genetic barrier to resistance to the integrase strand transfer inhibitor (INSTI) dolutegravir has been reported in vitro and in vivo. We describe the dynamics of INSTI resistance-associated mutations (INSTI-RAMs) and mutations in the 3'-polypurine tract (3'-PPT) in relation to virologic failure (VF) observed in the randomized Dolutegravir as Maintenance Monotherapy for HIV-1 study (DOMONO,...
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