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Article

Specific mutations in the HIV-1 G-tract of the 3'-polypurine tract cause resistance to integrase strand transfer inhibitors.

The Journal of antimicrobial chemotherapy - 23 Feb 2022

Hachiya Atsuko, Kubota Mai, Shigemi Urara, Ode Hirotaka, Yokomaku Yoshiyuki, Kirby Karen A, Sarafianos Stefan G, Iwatani Yasumasa

Abstract excerpt

BACKGROUND: In vitro selection experiments identified viruses resistant to integrase strand transfer inhibitors (INSTIs) carrying mutations in the G-tract (six guanosines) of the 3'-polypurine tract (3'-PPT). A clinical study also reported that mutations in the 3'-PPT were observed in a patient receiving dolutegravir monotherapy. However, recombinant viruses with the 3'-PPT mutations that were found in the...

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Identifiers

PMID: 34894227
DOI: 10.1093/jac/dkab448
PMCID: PMC8865006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

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Specific mutations in the HIV-1 G-tract of the 3'-polypurine tract cause resistance to integrase strand transfer inhibitors.PMID 34894227Read ↗

Mutations in the HIV-1 3′-Polypurine Tract and Integrase Strand Transfer Inhibitor ResistanceSemantic proximity Read ↗

INSTIs and NNRTIs Potently Inhibit HIV-1 Polypurine Tract Mutants in a Single Round Infection Assay.Semantic proximity Read ↗

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Mutations Located outside the Integrase Gene Can Confer Resistance to HIV-1 Integrase Strand Transfer Inhibitors.Semantic proximity Read ↗

HIV-1 Integrase Inhibitors That Are Broadly Effective against Drug-Resistant Mutants.Semantic proximity Read ↗

Characterization of the R263K Mutation in HIV-1 Integrase That Confers Low-Level Resistance to the Second-Generation Integrase Strand Transfer Inhibitor DolutegravirSemantic proximity Read ↗

Mutations in the 3'-PPT Lead to HIV-1 Replication without Integration.Semantic proximity Read ↗

HIV-1 3΄ polypurine tract mutations and integrase inhibitor resistance.Semantic proximity Read ↗

Dolutegravir, the Second-Generation of Integrase Strand Transfer Inhibitors (INSTIs) for the Treatment of HIVSemantic proximity Read ↗

Variability of the HIV-1 3' polypurine tract (3'PPT) region and implication in integrase inhibitor resistance.Semantic proximity Read ↗

Dolutegravir Resistance Mutation R263K Cannot Coexist in Combination with Many Classical Integrase Inhibitor Resistance SubstitutionsSemantic proximity Read ↗

Integrase strand transfer inhibitor (INSTI)-resistance mutations for the surveillance of transmitted HIV-1 drug resistanceSemantic proximity Read ↗

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