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Article

HIV drug resistance against strand transfer integrase inhibitors.

Retrovirology - 5 Jun 2017

Anstett Kaitlin, Brenner Bluma, Mesplede Thibault, Wainberg Mark A

Abstract excerpt

Integrase strand transfer inhibitors (INSTIs) are the newest class of antiretroviral drugs to be approved for treatment and act by inhibiting the essential HIV protein integrase from inserting the viral DNA genome into the host cell's chromatin. Three drugs of this class are currently approved for use in HIV-positive individuals: raltegravir (RAL), elvitegravir (EVG), and dolutegravir (DTG), while cabotegravir...

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Share to Anti-HIV Agents
Share to Drug Resistance, Viral
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to HIV Integrase

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Share to Selection, Genetic

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Identifiers

PMID: 28583191
DOI: 10.1186/s12977-017-0360-7
PMCID: PMC5460515

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