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Article

Variability of the HIV-1 3' polypurine tract (3'PPT) region and implication in integrase inhibitor resistance.

The Journal of antimicrobial chemotherapy - 1 Dec 2019

Malet Isabelle, Delelis Olivier, Nguyen Thuy, Leducq Valentin, Abdi Besma, Morand-Joubert Laurence, Calvez Vincent, Marcelin Anne-Geneviève

Abstract excerpt

BACKGROUND: Integrase strand-transfer inhibitors (INSTIs) are efficient at impairing retroviral integration, which is a critical step in HIV-1 replication. To date, resistance to these compounds has been explained by mutations in the viral protein integrase, which catalyses the integration step. Recently, it has been shown that selected mutations in the 3' polypurine tract (3'PPT), a sequence involved in the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 31730161
DOI: 10.1093/jac/dkz377

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Variability of the HIV-1 3' polypurine tract (3'PPT) region and implication in integrase inhibitor resistance.PMID 31730161Read ↗

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