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Article

Hormone-Dependent Prostate Cancers are Dependent on Rac Signaling for Growth and Survival

15 Mar 2021

Abstract excerpt

Prostate cancer remains a common cause of cancer mortality in men. Initially, cancers are dependent of androgens for growth and survival. First line therapies reduce levels of circulating androgens or target the androgen receptor (AR) directly. Although most patients show durable responses, many patients eventually progress to castration-resistant prostate cancer (CRPC) creating a need for alternative treatment...

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PMID: 33722851
DOI: 10.1158/1535-7163.mct-20-0695

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