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Article

Reciprocal regulation between RACGAP1 and AR contributes to endocrine therapy resistance in prostate cancer

19 Jun 2024

Abstract excerpt

BACKGROUND: Endocrine resistance driven by sustained activation of androgen receptor (AR) signaling pathway in advanced prostate cancer (PCa) is fatal. Characterization of mechanisms underlying aberrant AR pathway activation to search for potential therapeutic strategy is particularly important. Rac GTPase-activating protein 1 (RACGAP1) is one of the specific GTPase-activating proteins. As a novel tumor...

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PMID: 38898473
DOI: 10.1186/s12964-024-01703-w

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