Article
ROBO1, a tumor suppressor and critical molecular barrier for localized tumor cells to acquire invasive phenotype: study in African-American and Caucasian prostate cancer models.
International journal of cancer - 1 Dec 2014
Parray Aijaz, Siddique Hifzur R, Kuriger Jacquelyn K, Mishra Shrawan K, Rhim Johng S, Nelson Heather H, Aburatani Hiroyuki, Konety Badrinath R, Koochekpour Shahriar, Saleem Mohammad
Abstract excerpt
High-risk populations exhibit early transformation of localized prostate cancer (CaP) disease to metastasis which results in the mortality of such patients. The paucity of knowledge about the molecular mechanism involved in acquiring of metastatic behavior by primary tumor cells and non-availability of reliable phenotype-discriminating biomarkers are stumbling blocks in the management of CaP disease. Here, we...
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