Article
Activation of Notch1 synergizes with multiple pathways in promoting castration-resistant prostate cancer.
Proceedings of the National Academy of Sciences of the United States of America - 18 Oct 2016
Stoyanova Tanya, Riedinger Mireille, Lin Shu, Faltermeier Claire M, Smith Bryan A, Zhang Kelvin X, Going Catherine C, Goldstein Andrew S, Lee John K, Drake Justin M, Rice Meghan A, Hsu En-Chi, Nowroozizadeh Behdokht, Castor Brandon, Orellana Sandra Y, Blum Steven M, Cheng Donghui, Pienta Kenneth J, Reiter Robert E, Pitteri Sharon J, Huang Jiaoti, Witte Owen N
Abstract excerpt
Metastatic castration-resistant prostate cancer (CRPC) is the primary cause of prostate cancer-specific mortality. Defining new mechanisms that can predict recurrence and drive lethal CRPC is critical. Here, we demonstrate that localized high-risk prostate cancer and metastatic CRPC, but not benign prostate tissues or low/intermediate-risk prostate cancer, express high levels of nuclear Notch homolog 1,...
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