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Article

Peptidomes and Structures Illustrate Two Distinguishing Mechanisms of Alternating the Peptide Plasticity Caused by Swine MHC Class I Micropolymorphism.

Frontiers in immunology - 1 Jan 2021

Wei Xiaohui, Wang Song, Li Zhuolin, Li Zibin, Qu Zehui, Wang Suqiu, Zou Baohua, Liang Ruiying, Xia Chun, Zhang Nianzhi

Abstract excerpt

The micropolymorphism of major histocompatibility complex class I (MHC-I) can greatly alter the plasticity of peptide presentation, but elucidating the underlying mechanism remains a challenge. Here we investigated the impact of the micropolymorphism on peptide presentation of swine MHC-I (termed swine leukocyte antigen class I, SLA-I) molecules via immunopeptidomes that were determined by our newly developed...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33717070
DOI: 10.3389/fimmu.2021.592447
PMCID: PMC7952875

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