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Article

The impact of micropolymorphism in Anpl-UAA on structural stability and peptide presentation.

International journal of biological macromolecules - 1 May 2024

Tang Ziche, Wang Suqiu, Du Liubao, Hu Dongmei, Chen Xiaoming, Zheng Hanyin, Ding Han, Chen Shiwen, Zhang Lin, Zhang Nianzhi

Abstract excerpt

Micropolymorphism significantly shapes the peptide-binding characteristics of major histocompatibility complex class I (MHC-I) molecules, affecting the host's resistance to pathogens, which is particularly pronounced in avian species displaying the "minimal essential MHC" expression pattern. In this study, we compared two duck MHC-I alleles, Anpl-UAA*77 and Anpl-UAA*78, that exhibit markedly different peptide...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38636758
DOI: 10.1016/j.ijbiomac.2024.131665

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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