Article
A combined prediction strategy increases identification of peptides bound with high affinity and stability to porcine MHC class I molecules SLA-1*04:01, SLA-2*04:01, and SLA-3*04:01.
Immunogenetics - 1 Feb 2016
Pedersen Lasse Eggers, Rasmussen Michael, Harndahl Mikkel, Nielsen Morten, Buus Søren, Jungersen Gregers
Abstract excerpt
Affinity and stability of peptides bound by major histocompatibility complex (MHC) class I molecules are important factors in presentation of peptides to cytotoxic T lymphocytes (CTLs). In silico prediction methods of peptide-MHC binding followed by experimental analysis of peptide-MHC interactions constitute an attractive protocol to select target peptides from the vast pool of viral proteome peptides. We have...
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