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Article

Combined HRAS and NRAS ablation induces a RASopathy phenotype in mice.

Cell communication and signaling : CCS - 17 Jun 2024

Fuentes-Mateos Rocío, García-Navas Rósula, Fernández-Infante Cristina, Hernández-Cano Luis, Calzada-Nieto Nuria, Juan Andrea Olarte-San, Guerrero Carmen, Santos Eugenio, Fernández-Medarde Alberto

Abstract excerpt

BACKGROUND: HRASKO/NRASKO double knockout mice exhibit exceedingly high rates of perinatal lethality due to respiratory failure caused by a significant lung maturation delay. The few animals that reach adulthood have a normal lifespan, but present areas of atelectasis mixed with patches of emphysema and normal tissue in the lung. METHODS: Eight double knockout and eight control mice were analyzed using...

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Identifiers

PMID: 38886790
DOI: 10.1186/s12964-024-01717-4
PMCID: PMC11184836

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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