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Article

Phenotypic and evolutionary implications of modulating the ERK-MAPK cascade using the dentition as a model.

Scientific reports - 30 Jun 2015

Marangoni Pauline, Charles Cyril, Tafforeau Paul, Laugel-Haushalter Virginie, Joo Adriane, Bloch-Zupan Agnès, Klein Ophir D, Viriot Laurent

Abstract excerpt

The question of phenotypic convergence across a signalling pathway has important implications for both developmental and evolutionary biology. The ERK-MAPK cascade is known to play a central role in dental development, but the relative roles of its components remain unknown. Here we investigate the diversity of dental phenotypes in Spry2(-/-), Spry4(-/-), and Rsk2(-/Y) mice, including the incidence of extra...

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Share to Adaptor Proteins, Signal Transducing
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26123406
DOI: 10.1038/srep11658
PMCID: PMC4485067

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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