IgM Autoantibodies to Complement Factor H in Atypical Hemolytic Uremic Syndrome

Abstract excerpt

Significance Statement Atypical hemolytic uremic syndrome (aHUS) is often related to complement dysregulation, but its pathophysiology remains unknown in at list 30% of patients. Anti-factor H autoantibodies of the IgG class are responsible for 10% of patients with aHUS; autoantibodies of IgM class have not been reported. The authors found anti-factor H IgM autoantibodies in seven of 186 patients with aHUS, with...

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